Tracking the science and conversation around suPAR.

Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated With Adverse Cardiovascular Outcomes in the General Population: Insights From the UK Biobank

In 33,963 UK Biobank participants followed for a median of roughly 14 years, a proteomics-based suPAR measure was associated with adverse cardiovascular outcomes.

Peer-reviewed longitudinal cohort · New research

Editorial contextThis study evaluated a proteomics-based measure in an observational cohort rather than an interchangeable clinical suPAR concentration.

From Marrow to Podocyte: Following the suPAR Trail

Caitlyn Vlasschaert reviews research on suPAR, proteinuric kidney disease, and podocyte injury, including supportive and conflicting findings.

Third-party scientific commentary

Editorial contextThe article discusses small patient samples and experimental models and emphasizes that the evidence does not establish suPAR testing for routine clinical practice.

Presented by Eleni Gavriilaki

Presentation: suPAR and GDF levels in endothelial injury syndromes

Eleni Gavriilaki discusses observational research on suPAR and GDF levels in a defined patient population and their associations with endothelial injury markers.

Third-party research interview · ASH 2024

Editorial contextLonger-term studies are needed to investigate outcome prediction; the presentation does not establish individual diagnostic or predictive performance.

Immune protein suPAR links viral infection, possible cause of kidney disease

A University of Michigan Health article examines research into suPAR as a possible link between viral infection and kidney injury, drawing on experimental models and a hospitalized COVID-19 cohort.

Third-party news article about peer-reviewed research

Editorial contextThe article discusses possible mechanisms and future research directions. It does not establish what an individual suPAR result means for kidney disease or clinical management.

suPAR and heart failure outcomes: research from the Emory Cardiovascular Biobank

Michigan Medicine reports on a prospective cohort study that found associations between plasma suPAR levels, heart failure outcomes, and mortality in the population studied.

Third-party news article about a prospective cohort study

Editorial contextThe underlying observational study measured plasma suPAR by ELISA. Its population-level findings do not validate the performance, clinical utility, or intended use of the suPARbio testing service.

Soluble urokinase plasminogen activator receptor and outcomes in HFpEF: A TOPCAT ancillary study

In a 406-participant TOPCAT ancillary cohort, higher baseline suPAR was associated with cardiovascular death, cardiac arrest, or heart-failure hospitalization after adjustment for other factors.

Peer-reviewed ancillary cohort study

Editorial contextA relatively small observational ancillary cohort cannot establish causality or support a standalone prognostic decision rule.

suPAR and systemic chronic inflammation: a scientific review

This review synthesizes research on how suPAR is produced, factors associated with circulating levels, and findings reported across chronic diseases.

Peer-reviewed narrative review

Editorial contextA narrative review, not clinical validation; an author reports suPAR-related patents and company interests.

Elevated suPAR and markers of accelerated aging

In the longitudinal Dunedin Study, elevated suPAR at midlife was associated with a faster measured pace of biological aging and differences in physical and cognitive function.

Peer-reviewed longitudinal cohort

Editorial contextOne midlife New Zealand cohort; the findings do not define a clinical cutoff or prove that suPAR drives aging.

suPAR and high-sensitivity C-reactive protein after bariatric surgery

In 48 adults undergoing bariatric surgery, hsCRP declined consistently while suPAR increased transiently before moving toward baseline over 12 months.

Peer-reviewed prospective observational study

Editorial contextThe small study demonstrates context-dependent biomarker behavior but does not establish clinical outcomes or intervention efficacy.

Elevated suPAR as a risk marker for incident kidney disease in acute medical patients

Among 25,497 acutely hospitalized medical patients, higher suPAR at emergency-department admission was associated with greater subsequent risk of chronic and acute kidney disease.

Peer-reviewed longitudinal clinical cohort

Editorial contextFindings from an acutely ill hospital population are observational and do not establish causality or a general clinical threshold.

Healthy lifestyles reduce suPAR and mortality in a Danish general population study

In 3,225 Inter99 participants, healthier lifestyle patterns were associated with lower longitudinal suPAR levels, while higher suPAR was associated with greater all-cause mortality during follow-up.

Peer-reviewed longitudinal population cohort

Editorial contextObservational associations do not establish that changing suPAR levels changes mortality or other health outcomes.

suPAR, dietary quality, and mortality in a Danish population cohort

In 5,347 Danish participants, lower dietary-quality scores were associated with higher suPAR, and higher suPAR was associated with greater all-cause mortality.

Peer-reviewed population cohort

Editorial contextThe observational design remains subject to residual confounding and does not establish causal relationships among diet, suPAR, and mortality.

suPAR and cardiovascular, kidney, and mortality outcomes in type 1 diabetes

In a cohort of 667 people with type 1 diabetes, higher suPAR was associated with cardiovascular events, kidney-function decline, and all-cause mortality.

Peer-reviewed observational cohort

Editorial contextThis disease-specific cohort does not establish causality or validate suPAR as a standalone clinical decision tool.

Analytical, biochemical, and clearance considerations for suPAR in healthy individuals

A study of 155 healthy adults examined analytical and biological factors that may influence circulating suPAR, including renal clearance, receptor biology, tissue expression, and physiological variability.

Peer-reviewed analytical and biological determinants study

Editorial contextThe small healthy-adult cohort does not define clinical reference ranges or establish interpretation across patient populations.

suPAR and kidney function in the Malmö population study

This population-based study examined suPAR in relation to impaired kidney function and subsequent decline, providing replication outside the original referred cohorts.

Peer-reviewed population cohort

Editorial contextObservational European cohort data; assay methods, baseline kidney function, and other risk factors can influence the relationship.

suPAR and future chronic kidney disease risk

This longitudinal study reported that higher suPAR levels were associated with declining kidney function and incident chronic kidney disease.

Peer-reviewed prospective cohort

Editorial contextThe human evidence is observational and comes from referred cardiovascular cohorts; kidney function and residual confounding affect interpretation.

Risk factors associated with circulating suPAR in a general population

In 5,538 Danish participants, smoking, age, and obesity were independently associated with higher suPAR, while the association with physical activity weakened after multivariable adjustment.

Peer-reviewed population-based observational study

Editorial contextAssociations between participant characteristics and suPAR do not establish directionality, causality, or clinical reference thresholds.

suPAR and long-term health outcomes in a Danish population cohort

In 2,602 Copenhagen adults followed for approximately 13 years, higher baseline suPAR was associated with cancer, cardiovascular disease, type 2 diabetes, and mortality.

Peer-reviewed prospective cohort

Editorial contextObservational findings from a predominantly White Danish cohort do not establish causation or a screening threshold.